How to apply istio to large networks Multi-networking across geographies

I read Istio / Deployment Models

thus understanding that istio supports multi-cluster deployments.

I have another question, how do the components used by istio support multiple clusters?
For example

  • Jaeger
  • Zipkin
  • cert-manager
  • Grafana
  • Kiall
  • Prometheus

As far as I know Prometheus could be using thanos to aggregate information at query time, then