Does it support Apply for certification for non-http TLS traffic via Istio + Cert-Manager + Let’s Encrypt

Hello Team,

In my scenario, I have a non-http TLS connection to istio ingress gateway, my client sits outside of cloud, and connect to istio ingress gateway via TLS rather than HTTP. I wish TLS connection can be terminated in istio ingress gateway, and TLS certification can be automatically retrieved via Cert-Manager.

My question is, could I use Cert-Manager + Let’s Encrypt to apply for certificate for our scenario? Because I see most cases are for https.

Thanks in advanced.