Does ServiceEntry definition for external IPs check the reachability?

I am planning to create a ServiceEntry from one of my Kubernetes cluster’s to another one. I have Ingress Nginx configured on the other cluster running on host port and planning to use IPs of workers and port 80 for service entry definition. I wonder whether the service definition will disable and won’t route the traffic to any of the IPs are not reachable or down? Is there any health check mechanism for ServiceEntry definition?