Istio control plane not accessible (theory)

I have a theoretical question. Let’s assume we have a multizone cluster for istio and the apps in the mesh. Seems that istio charts does not support a full assignment to the zones, so it might be possible that “istio control plane pods” would go to zone1. And some app pods with the istio-proxies to zone2.
If the above is a possible scenario, what will happen if we lose zone1 for whatever reason?
Would zone2 pods with the istio-proxies be able to manage traffic until for Example Kubernetes reschedule the missing nodes and pods etc, so reestablish the istio control plane.

In case anyone has experience with similar case, please share. thanks