Istio: Application/Service timing out

Hi All,
We have an architecture like myProxy->Istio->Apps/services. And whenever the app response times out, istio doesn’t return anything to myProxy for long time(until the idle connection timeout on myProxy expired). I want to know how do we handle this kind of scenario in istio, would setting idle connection timeout on istio to a lower value work? Or can istio respond with connection:close header? Any help is greatly appreciated!