Primary-Remote Setup (Istio-Proxy failed to connect to remote after sometime)

Primary-Remote-Setup:
I was working earlier, however, after sometime I see the following error message:
warning envoy config StreamAggregatedResources gRPC config stream closed since 33s ago: 14, connection error: desc = “transport: authentication handshake failed: read tcp :39772->:15012: read: connection reset by peer”

kubectl version --short
Client Version: v1.21.9
Server Version: v1.21.12+vmware.1

PeerAuthentication: PERMISSIVE

apiVersion: install.istio.io/v1alpha1
kind: IstioOperator
spec:
values:
global:
meshID: mesh1
multiCluster:
clusterName: secondary
network: network2
remotePilotAddress: istio-eastwestgateway-IP-Primary-Cluster

Istio-ingressproxy logs duing initial setup:
2023-02-03T04:32:49.315857Z info Readiness succeeded in 2.765891258s
2023-02-03T04:32:49.316178Z info Envoy proxy is ready
2023-02-03T05:03:03.235278Z info xdsproxy connected to upstream XDS server: istiod-remote.istio-system.svc:15012
2023-02-03T20:54:53.095076Z warning envoy config StreamAggregatedResources gRPC config stream closed since 39s ago: 14, connection error: desc = “transport: authentication handshake failed: read tcp 198.18.112.228:38280->10.152.150.13:15012: read: connection reset by peer”