i/o timeout problem

Greetings, I have a problem with Istio and Calico.

The k8s cluster had a problem with i/o timeout.
The related logs is in here

I don’t know how to further troubleshoot.

Edit 1: Adding the application versions : k8s: 1.19.0, istio 1.9.0, calico 3.17.0. All on virtual machines. Installed via kubeadm.

Any help is appreciated, thanks.